Central Centrifugal Cicatricial Alopecia: Past, Present, and Future

March 2009 in “ Journal of The American Academy of Dermatology ”

Raechele Cochran Gathers, Henry W. Lim

central centrifugal cicatricial alopecia CCCA hair loss chemical relaxers scarring alopecia topical corticosteroids intralesional corticosteroids oral anti-inflammatory agents hair grooming practices damaging hair care practices

TLDR CCCA is a hair loss type affecting African women, possibly caused by grooming and chemicals, with various treatments and needing more research.

This document from 2009 discusses central centrifugal cicatricial alopecia (CCCA), a form of hair loss that primarily affects women of African descent. The causes of CCCA are still debated, but it is believed to be related to hair grooming practices and chemical relaxers. The article explores the controversy surrounding whether CCCA is a distinct clinicopathologic entity or whether histopathologic changes are non-specific and seen in other forms of scarring alopecia. Treatment options include topical and intralesional corticosteroids, oral anti-inflammatory agents, and avoidance of damaging hair care practices. The document emphasizes the need for further research to better understand and treat this form of alopecia.

View this study on jaad.org →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Histopathologic Evaluation of Alopecias

90 citations , June 2006 in “The American Journal of Dermatopathology”

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.

research The Medical Treatment of Cicatricial Alopecia

46 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

Current treatments for cicatricial alopecia can manage symptoms but don't stop hair loss or the disease.

research Hair Loss: Is There a Relationship with Hair Care Practices in Nigeria?

57 citations , September 2005 in “International Journal of Dermatology”

Frequent use of chemical hair relaxants is linked to increased scarring hair loss in Nigerian women.

research Medical and Surgical Therapies for Alopecias in Black Women

105 citations , April 2004 in “Dermatologic Therapy”

The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.

research Hair and Scalp Disorders in Ethnic Populations

55 citations , October 2003 in “Dermatologic Clinics”

Different hair care practices and conditions affect African American hair and scalp health, requiring specialized knowledge for treatment.

research Ethnic Hair Update: Past and Present

73 citations , June 2003 in “Journal of the American Academy of Dermatology”

Dermatologists need to understand African American hair-care practices to better treat their hair and scalp disorders.

research A Nationwide Outbreak of Alopecia Associated With the Use of a Hair-Relaxing Formulation

54 citations , September 2000 in “Archives of dermatology”

A hair-straightening product caused widespread hair loss and scalp injuries, mainly affecting African American women.

research Hot Comb Alopecia

14 citations , September 1968 in “Archives of Dermatology”

Using hot combs can cause permanent hair loss on the scalp's crown.

Related Community Posts Join

6 / 113 results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 90 upvotes 1 year ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 3 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community scarring alopecia awareness in this community

in Chat 33 upvotes 3 years ago

Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 6 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 2 years ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

Related Research

7 / 7 results

research Clinical Recognition and Management of Alopecia in Women of Color

5 citations , August 2019 in “International Journal of Women's Dermatology”

The document concludes that it's important to recognize and treat hair loss in women of color, considering their unique hair characteristics and psychological impact.

research Changes in the Hair Growth Cycle in Women with Non-Scarring Alopecia

October 2018 in “Vestnik dermatologii i venerologii”

Certain growth factors affect hair loss in women and could be targeted for treatment.

research Efficacy of Topical Tofacitinib in Promoting Hair Growth in Non-Scarring Alopecia

April 2018 in “Journal of Investigative Dermatology”

Topical tofacitinib is effective in promoting hair growth for non-scarring alopecia.

research Disorders of Hair

July 2013 in “DeckerMed Medicine”

The document's conclusion cannot be provided because the document is not readable or understandable.

Central Centrifugal Cicatricial Alopecia: Past, Present, and Future