Dermal Mucin in Alopecia Areata: Tell-Tale Sign or Incidental Finding?

    July 2008 in “ Journal of Cutaneous Pathology ”
    Lynne J. Goldberg, Vinoo Sekhri, Jag Bhawan
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    TLDR Increased mucin in the skin might indicate lupus in patients with hair loss, but more research is needed.
    In the 2008 study, researchers examined the presence of dermal mucin in a patient with both systemic lupus erythematosus (SLE) and alopecia areata, finding a significant increase in mucin in the deep dermis and subcutis. They extended their investigation to 13 additional biopsies of alopecia areata, discovering mild and superficial mucin deposition in 3 cases (23%). The findings suggested that pronounced mucin deposition might be indicative of underlying SLE in alopecia areata patients, but the authors emphasized the need for larger studies to confirm this potential diagnostic marker.
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