Histopathology of non-scarring alopecia
April 1995
in “Journal of Cutaneous Pathology”
TLDR The document describes how to tell different types of non-scarring hair loss apart by looking at hair and scalp tissue under a microscope.
The document from 1995 provides a comprehensive overview of the histopathological features of non-scarring alopecia, including alopecia areata, androgenetic alopecia, senescent alopecia, telogen effluvium, trichotillomania, traction alopecia, pressure-induced alopecia, syphilitic alopecia, systemic lupus erythematosus-related alopecia, temporal triangular alopecia, and loose anagen hair syndrome. It highlights the importance of recognizing normal versus abnormal follicular architecture for diagnosis and describes the typical histological findings for each condition, such as the presence of miniaturized hair follicles, increased telogen count, and perifollicular inflammation. The document also notes that in non-scarring alopecia, the total number of hair follicles is usually normal, but there may be changes in the hair cycle phases or follicle size. It emphasizes that inflammation is not always diagnostic due to its presence in normal scalps. The document does not provide specific data on the number of people studied and acknowledges Purnima Sau for contributing histologic material. The views expressed are those of the authors and not the official views of the U.S. Army or the Department of Defense.
View this study on onlinelibrary.wiley.com →
Cited in this study
research Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia
Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.
research Telogen Effluvium
Telogen effluvium is a reversible hair loss condition that requires a detailed diagnosis and often resolves on its own.
research Loose Anagen Hair as a Cause of Hereditary Hair Loss in Children
Loose Anagen Hair Syndrome is a hereditary condition causing hair loss in children due to abnormal hair follicles.
research Hair anatomy for the clinician
Understanding hair follicle anatomy helps diagnose hair disorders.
research The Transverse Anatomy of Androgenic Alopecia
The study found that horizontal sections of scalp biopsies are better for analyzing hair loss, showing fewer hairs and more fine hairs in balding areas.
research Androgenetic Alopecia: Clinical Aspects and Treatment
research Loose anagen hair of childhood: The phenomenon of easily pluckable hair
Children with loose anagen hair have easily pluckable hair due to root sheath problems, and it might improve without treatment.
research Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp
Minoxidil promotes hair growth but exact mechanism is unknown.
research Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia
Minoxidil can help grow hair and make hair follicles bigger, but it can also cause side effects.