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GlossaryMonocyte Chemoattractant Protein-1 (CCL2)

signaling protein that attracts monocytes to inflammation sites

Monocyte Chemoattractant Protein-1 (MCP-1), also known as CCL2, is a signaling protein that plays a crucial role in the immune system by attracting monocytes, a type of white blood cell, to sites of inflammation or injury. This protein is important in the body's response to infection and tissue damage, but excessive MCP-1 activity can contribute to chronic inflammatory diseases.

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research Expression of Vascular Endothelial Growth Factor, Apoptosis Inhibitors (Survivin and p16) and CCL27 in Alopecia Areata Before and After Diphencyprone Treatment: An Immunohistochemical Study

58 citations , May 2004 in “British Journal of Dermatology”

Diphenylcyclopropenone treatment helps hair growth in alopecia areata by promoting blood vessel growth and cell survival.

research Mechanical stimuli-induced CCL2 restores adult mouse cells to regenerate hair follicles

18 citations , March 2023 in “Molecular Therapy — Nucleic Acids”

Mechanical stimuli and CCL2 can help regenerate hair follicles in adult mice.

research Novel Diagnostic Tools and Markers for Inflammatory Skin Diseases

January 2016 in “mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)”

A new test using NOS2 and CCL27 genes can better diagnose and treat psoriasis and eczema.

research Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

286 citations , June 2012 in “Nature Immunology”

Hair follicles help attract immune cells to the skin during stress.

research Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

236 citations , April 2015 in “Cell”

Plucking some hairs can trigger nearby unplucked hairs to grow back more due to a collective response.

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community Aromatase Upregulation along with DHT down regulation could possibly hold the cure

in Microneedling 7 upvotes 3 years ago

The post discusses the potential of upregulating aromatase to treat hair loss, suggesting that increasing CCL2 levels through Vitamin D or microneedling might help. The user questions why microneedling doesn't work for everyone, especially those with advanced hair loss.