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GlossaryIsthmus of Hair Follicle (Isthmus)

region between the infundibulum and bulge area of hair follicle

The isthmus of the hair follicle is a specific region located between the infundibulum (the upper part of the follicle) and the bulge area (where stem cells reside). This section plays a crucial role in the structural integrity and function of the hair follicle, including the anchoring of the hair shaft and the regulation of hair growth cycles.

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research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.

research Alopecia Areata with Lymphocytic Mural Folliculitis Affecting the Isthmus in a Thoroughbred Mare

14 citations, August 2004 in “Veterinary Dermatology”

The horse had a rare type of hair loss caused by immune cells attacking hair follicles.

research Epithelial Stem Cells And Implications For Wound Repair

156 citations, October 2012 in “Seminars in Cell & Developmental Biology”

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

research Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice

86 citations, May 2002 in “Journal of comparative neurology”

Nerve growth in mouse skin and hair follicles happens in stages and is closely linked to hair development.

Morphometric Analysis of the Human Scalp Hair Follicle: Practical Implications for the Hair Transplant Surgeon and Hair Regeneration Studies

research Morphometric Analysis of the Human Scalp Hair Follicle: Practical Implications for the Hair Transplant Surgeon and Hair Regeneration Studies

51 citations, November 2010 in “Dermatologic Surgery”

The research provides specific measurements for hair follicles that can improve hair transplant and regeneration techniques.

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community Progress but at different times?

in Is this regrowth? 6 upvotes 7 months ago

The user has been taking 1.25mg of oral minoxidil and 1mg of finasteride for a year and added topical minoxidil in January. They noticed hair improvement but are experiencing uneven regrowth, with the hairline improving and the middle part worsening.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.