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GlossaryIsthmus of Hair Follicle (Isthmus)

region between the infundibulum and bulge area of hair follicle

The isthmus of the hair follicle is a specific region located between the infundibulum (the upper part of the follicle) and the bulge area (where stem cells reside). This section plays a crucial role in the structural integrity and function of the hair follicle, including the anchoring of the hair shaft and the regulation of hair growth cycles.

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research Pulling Force Deforms Hair Follicle Root Sheath Nuclei and Surrounding Dermal Collagen Matrix Differently at Infundibulum, Isthmus, and Suprabulbar Regions

2 citations , April 2019 in “Experimental Dermatology”

Hair follicles respond differently to pulling forces in various regions.

research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.

research Morphologic and Immunologic Characterization of a Canine Isthmus Mural Folliculitis Resembling Pseudopelade of Humans

13 citations , March 2000 in “Veterinary Dermatology”

Dogs have a skin condition like human pseudopelade, causing hair loss that doesn't improve with treatment.

research Alopecia Areata with Lymphocytic Mural Folliculitis Affecting the Isthmus in a Thoroughbred Mare

14 citations , August 2004 in “Veterinary Dermatology”

The horse had a rare type of hair loss caused by immune cells attacking hair follicles.

research Seborrheic karatosis, a tumor of the infundibular and isthmus of hair follicles: Identification of hair sheath keratins and histopathological features suggesting hair follicle origin.

2 citations , January 1989 in “The Nishinihon Journal of Dermatology”

Seborrheic keratosis likely originates from the upper regions of hair follicles.

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community Progress but at different times?

in Is this regrowth? 6 upvotes 1 year ago

The user has been taking 1.25mg of oral minoxidil and 1mg of finasteride for a year and added topical minoxidil in January. They noticed hair improvement but are experiencing uneven regrowth, with the hairline improving and the middle part worsening.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 2 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Quote from Pelage (PP-405) Spokesperson...

in Research/Science 121 upvotes 3 weeks ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.