Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein
November 2023
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
keratinocytes upper epidermis isthmus of hair follicles hemoglobin mRNA hemoglobin protein Hemoglobin Alpha HBA oxidative stress UV irradiation human epidermal keratinocytes skin barrier function immunofluorescence staining RNA isolation RT-qPCR analysis microarray analysis single-cell RNA-sequencing analysis RNA interference cellular ROS staining skin cells hair follicle region hemoglobin UV light exposure skin protection fluorescent staining RNA extraction quantitative PCR gene expression analysis single-cell RNA sequencing gene silencing reactive oxygen species staining
Studysummary This study suggests that hemoglobin α expression in the epidermis is induced by oxidative stress and may function as an antioxidant, contributing to skin barrier function.
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