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GlossaryIsthmus of Hair Follicle

region between the infundibulum and bulge area of hair follicle

The isthmus of the hair follicle is a specific region located between the infundibulum (the upper part of the follicle) and the bulge area (where stem cells reside). This section plays a crucial role in the structural integrity and function of the hair follicle, including the anchoring of the hair shaft and the regulation of hair growth cycles.

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research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.

Evaluation of Perifollicular Inflammation of Donor Area During Hair Transplantation in Androgenetic Alopecia and Its Comparison With Controls

research Evaluation of Perifollicular Inflammation of Donor Area During Hair Transplantation in Androgenetic Alopecia and Its Comparison With Controls

13 citations, January 2013 in “International Journal of Trichology”

Inflammation around hair follicles may worsen hair loss; evaluating and treating it can improve transplant results.

research Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate In Vivo Epidermal Structures

10 citations, June 2016 in “Cell Transplantation”

Sebaceous glands can help harvest hair follicle stem cells to regenerate skin and hair.

research Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit

9 citations, September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.

research In-Vitro and In-Vivo Study of Dye Diffusion into the Human Skin and Hair Follicles

9 citations, November 2000 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE”

Dyeing hair can help target and destroy hair follicles selectively.

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community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Progress but at different times?

in Is this regrowth? 6 upvotes 7 months ago

The user has been taking 1.25mg of oral minoxidil and 1mg of finasteride for a year and added topical minoxidil in January. They noticed hair improvement but are experiencing uneven regrowth, with the hairline improving and the middle part worsening.