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GlossaryInfundibular Region

upper part of a hair follicle below skin's surface

The infundibular region refers to the upper part of a hair follicle, just below the opening of the follicle at the skin's surface. This area is crucial for the passage of sebum and other substances from the sebaceous glands to the skin, and it plays a significant role in conditions like acne and folliculitis.

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research Stem Cell Markers (Cytokeratin 15, CD34, and Nestin) in Primary Scarring and Nonscarring Alopecia

54 citations, January 2009 in “British Journal of Dermatology”

Scarring alopecia affects different hair follicle stem cells than nonscarring alopecia, and the infundibular region could be a new treatment target.

research Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp

100 citations, September 1999 in “British Journal of Dermatology”

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

research D2-40 Expression in Primary Scarring and Nonscarring Alopecia

3 citations, April 2010 in “The American Journal of Dermatopathology”

Most people with scarring and nonscarring hair loss show similar D2-40 levels, but some with scarring hair loss have higher levels.

research Clinicopathological Characteristics of Fibrosing Alopecia in a Pattern Distribution: A Single-Center, Retrospective Study

April 2023 in “Journal of Investigative Dermatology”

The study suggests fibrosing alopecia in a pattern distribution has distinct features and may vary by race.

research Disturbance of Immune Microenvironment in Androgenetic Alopecia Through Spatial Transcriptomics

August 2024 in “International Journal of Molecular Sciences”

Androgenetic alopecia involves immune cell disruptions, especially increased CD4+ T cells around hair follicles.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 2 weeks ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 9 months ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.