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Glossary Infundibular Region

upper part of a hair follicle below skin's surface

The infundibular region refers to the upper part of a hair follicle, just below the opening of the follicle at the skin's surface. This area is crucial for the passage of sebum and other substances from the sebaceous glands to the skin, and it plays a significant role in conditions like acne and folliculitis.

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research Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions

2 citations , April 2019 in “Experimental Dermatology”

This study observed that applying a pulling force to hair follicles led to significant compression of nuclei in certain cell layers and distinct collagen changes at different follicle depths.

research Seborrheic karatosis, a tumor of the infundibular and isthmus of hair follicles: Identification of hair sheath keratins and histopathological features suggesting hair follicle origin.

2 citations , January 1989 in “The Nishinihon Journal of Dermatology”

This study found that seborrheic keratosis lesions contain high levels of hair sheath keratin, suggesting they may originate from the upper hair follicle.

research Immunohistochemical localization of types 1 and 2 5α-reductase in human scalp

100 citations , September 1999 in “British Journal of Dermatology”

This study suggests that finasteride's effect on promoting hair growth in men with androgenetic alopecia may be due to its inhibition of 5aR2 localized in hair follicles.

research Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia

54 citations , January 2009 in “British Journal of Dermatology”

This study found that in scarring alopecia, stem cells are differentially localized, suggesting that both inner and outer root sheath stem cells, rather than just follicular bulge stem cells, are involved.

research Tight junctions form a barrier in porcine hair follicles

21 citations , December 2015 in “European journal of cell biology”

In this study, researchers demonstrated that follicular tight junctions in porcine skin form a barrier to nanoparticle penetration, particularly in upper regions, which supports its use as a model for human skin.

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community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 11 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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