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GlossaryInfundibular Hyperkeratosis

excessive keratin buildup in hair follicle's upper part

Infundibular Hyperkeratosis refers to the excessive buildup of keratin (a protein that makes up the outer layer of the skin) within the infundibulum, which is the upper part of a hair follicle. This condition can lead to clogged hair follicles, potentially causing skin issues like acne or folliculitis.

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research Follicular and Perforating Disorders

11 citations, June 1985 in “Journal of cutaneous pathology”

Examining many sections is key to correctly diagnosing hair follicle disorders.

research Line-Field Confocal Optical Coherence Tomography: A New Diagnostic Method of Lichen Planopilaris

1 citations, October 2023 in “Skin research and technology”

LC-OCT is an effective new method for diagnosing classic lichen planopilaris.

research The Potential Role of Acetylcholine Receptors in Acne Inversa Pathogenesis

1 citations, June 2006 in “Experimental dermatology”

Acetylcholine receptors might be involved in the development of acne inversa and smoking could worsen the condition.

research Hidradenitis Suppurativa: A Review of Cause and Treatment

73 citations, December 2010 in “Current opinion in infectious diseases/Current opinion in infectious diseases, with evaluated MEDLINE”

Hidradenitis suppurativa is a skin condition possibly caused by hair follicle issues, with treatments focusing on infection and inflammation.

research Deciphering the Functions of the Hair Follicle Infundibulum in Skin Physiology and Disease

38 citations, September 2014 in “Cell and Tissue Research”

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

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community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 2 weeks ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 9 months ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.