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GlossaryInfundibulum

funnel-shaped upper part of a hair follicle

The infundibulum is the funnel-shaped upper part of a hair follicle, located just below the opening of the follicle at the skin's surface. It plays a crucial role in guiding the hair shaft as it grows and emerges from the skin, and it also serves as a pathway for sebum and other substances to reach the skin's surface.

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research Microneedling Dilates the Follicular Infundibulum and Increases Transfollicular Absorption of Liposomal Sepia Melanin

25 citations , June 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Microneedling helps increase the absorption of a melanin product into hair follicles, which may improve laser hair removal effectiveness.

Reflectance Confocal Microscopy Can Differentiate Dermoscopic White Dots of the Scalp Between Sweat Gland Ducts or Follicular Infundibulum

research Reflectance Confocal Microscopy Can Differentiate Dermoscopic White Dots of the Scalp Between Sweat Gland Ducts or Follicular Infundibulum

20 citations , April 2011 in “British Journal of Dermatology”

Reflectance confocal microscopy can tell apart white dots on the scalp as either sweat gland ducts or hair follicle openings.

research Upregulation of Interfollicular Epidermal and Hair Infundibulum β-Catenin Expression in Gsdma3 Mutant Mice

11 citations , June 2012 in “Acta histochemica”

Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.

research The Presence of Antioxidants in the Hair Infundibulum: Implications in Hair Diseases Such as Alopecia

June 2022 in “International Journal of Research -GRANTHAALAYAH”

Antioxidants like catalase are important for preventing hair loss conditions like alopecia.

research New Insights on Dandruff/Seborrhoeic Dermatitis: The Role of the Scalp Follicular Infundibulum in Effective Treatment Strategies

46 citations , September 2011 in “British journal of dermatology/British journal of dermatology, Supplement”

Effective dandruff treatment requires delivering antifungal agents to the scalp follicular infundibulum.

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community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 2 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Is Finasteride the only way to reduce scalp DHT?

in Chat 19 upvotes 1 day ago

A 24-year-old male experienced side effects like low libido and ED after starting finasteride post-hair transplant and is seeking alternatives to reduce scalp DHT. Suggestions include topical finasteride, Xpecia, DHT-reducing shampoos, and switching to dutasteride, with some users reporting fewer side effects with these alternatives.

community Quote from Pelage (PP-405) Spokesperson...

in Research/Science 121 upvotes 1 week ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 10 months ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

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