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research Anogenital Distance as a Biomarker for Incomplete Masculinization: Molecular Mechanisms in the Perineum
This study concludes that anti-androgenic chemicals causing short anogenital distance in male fetuses also induce a feminized transcriptional profile in the perineum, implicating Wnt and estrogen signaling in the process.
research Mixture Effects of Endocrine Disrupting Compounds In Vitro
This study concluded that mixtures of weak endocrine disruptors, such as parabens and azole fungicides, can produce combination effects that should be considered in regulatory risk assessments to avoid underestimating potential risks.
research Identification and Molecular Characterization of a New Ovarian Cancer Susceptibility Locus at 17q21.31
This study found several microRNA-related genetic variants linked to epithelial ovarian cancer risk, with a notable association at the 17q21.31 region, suggesting potential new susceptibility genes.
research Characterization of the In Vitro, Ex Vivo, and In Vivo Efficacy of the Antimicrobial Peptide DPK-060 for Topical Treatment
This study found that the antimicrobial peptide DPK-060 effectively reduced bacterial counts of Staphylococcus aureus and was safe for topical use in preclinical models, although nanocarrier encapsulation did not enhance its efficacy.
research Erosive Pustular Dermatosis of the Scalp: Clinical, Trichoscopic, and Histopathologic Features of 20 Cases
In this study of 20 patients with erosive pustular dermatosis of the scalp, using trichoscopy improved diagnosis, and treatments with high-potency steroids or topical tacrolimus effectively reduced inflammatory signs, suggesting these as first-line treatments.
research Exploiting Unique Features of Microneedles to Modulate Immunity
This review discusses the unique advantages and challenges of microneedle arrays for vaccine and immunotherapy delivery but reports no new clinical results.
research Alkaline Ceramidase 1 Is Essential for Mammalian Skin Homeostasis and Regulating Whole-Body Energy Expenditure
This study found that mice lacking alkaline ceramidase 1 with elevated skin ceramide levels showed disrupted skin homeostasis, including altered hair follicle structures, increased water loss, and a hypermetabolism phenotype.
research New Onset of Alopecia Areata in a Patient with SARS-CoV-2 Infection: Possible Pathogenetic Correlations
This letter to the editor discusses a potential link between new onset alopecia areata and SARS-CoV-2 infection, but reports no new clinical results.
research Metabolic Syndrome Prevalence in Psoriasis
People with psoriasis are more likely to have Metabolic Syndrome than those without psoriasis.
research Telogen Effluvium After SARS-CoV-2 Infection: A Series of Cases and Possible Pathogenetic Mechanisms
This study observed that telogen effluvium, or acute hair loss, often occurs 1 to 3 months after SARS-CoV-2 infection, earlier than classic telogen effluvium.
research 5-Alpha-Reductase 2 Inhibition Impairs Brain Defeminization of Male Rats: Reproductive Aspects
This study found that inhibiting the 5alpha-reductase 2 pathway in male rats affects brain sexual differentiation and leads to reproductive changes, including increased pre-implantation loss despite unchanged copulatory potential.
research Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses
This study reports that chemically induced short anogenital distance in male rat fetuses involved distinctive transcriptional changes, suggesting roles for estrogen and Wnt2 signaling in anogenital tissue development.
research Topical Administration of 15-Deoxy-Δ12,14-Prostaglandin J2 Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice
In this study, 15d-PGJ2 administered in a topical cream inhibited oxidative and inflammatory skin changes caused by UVB radiation in hairless mice, suggesting it as a promising treatment approach.
research Factors Regulating Quiescent Stem Cells: Insights from the Intestine and Other Self-Renewing Tissues
This review examines regulatory mechanisms of quiescent stem cells in tissue homeostasis, drawing on observations from the intestine and other self-renewing tissues, without presenting new data.
research Southern African HIV Clinicians Society Gender-Affirming Healthcare Guideline for South Africa
The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.
research Erosive Pustular Dermatosis of the Scalp: A Clinicopathologic Study of Fifty Cases
This study suggests that erosive pustular dermatosis of the scalp may be part of the spectrum of autoinflammatory dermatoses, rather than a unique skin disorder.
research Tail Tales: What We Have Learned About Regeneration from Xenopus Laevis Tadpoles
This review highlights the regenerative abilities of *Xenopus laevis*, focusing on how tadpoles regrow complex tail structures and the cellular and molecular mechanisms behind this. It underscores *X. laevis* as a valuable model for understanding regeneration, with insights potentially advancing regenerative medicine.
research Efficacy of Upadacitinib in Treating Alopecia Areata, Atopic Dermatitis, and Th1 Comorbidities in Pediatric Patients: A Comprehensive Case Series and Literature Review
This study reported that in a case series of three adolescents with alopecia areata and atopic dermatitis, treatment with 15 mg/day of upadacitinib led to rapid improvement in skin symptoms and significant hair regrowth over 12 months, with no severe adverse events observed.
research First Use of Cord Blood Platelet-Rich Plasma in the Treatment of Vulvar Lichen Sclerosus: A Preliminary Study Towards a Randomized Controlled Trial.
This pilot study found that cord blood platelet-rich plasma treatment was safe and improved symptoms and sexual function in women with vulvar lichen sclerosus after standard topical corticosteroid treatment.
research Complete Pseudo-Anodontia in an Adult Woman with Pseudo-Hypoparathyroidism Type 1a: A New Additional Nonclassical Feature?
This case report identifies a 32-year-old woman with undiagnosed PHPT-1a who exhibited complete pseudo-anodontia and persistent patchy alopecia areata, suggesting these may be new nonclassical features of a GNAS pathogenic variant.