D2-40 Expression in Primary Scarring and Nonscarring Alopecia

In the 2010 study examining D2-40 expression in alopecia, researchers analyzed 52 cases, including 33 with scarring alopecia and 19 with nonscarring alopecia. They found that 73% of scarring alopecia cases had similar D2-40 expression to nonscarring cases, while 27% showed increased expression, particularly in the infundibular region. In contrast, 90% of nonscarring alopecia cases had similar D2-40 expression, with 10% showing no expression. The study did not link increased D2-40 expression to specific histologic diagnoses but suggested that Fos-dependent transcription mechanisms might be involved in the etiopathogenesis of some scarring alopecias. Further research was deemed necessary to understand the role of the Fos-podoplanin axis in hair follicle development and its potential involvement in the pathogenesis of scarring alopecias.