17 citations
,
March 2005 in “Journal of Investigative Dermatology”
This study found that human hairfollicle bulge stem cells exhibited autofluorescence, potentially due to high flavin- and NAD-related compound levels, highlighting the need to consider this when using fluorescent antibodies for studying these cells.
9 citations
,
June 1999 in “Journal of Investigative Dermatology”
This study observed hair-specific transcription of a reporter gene in transgenic mice, with increased expression after dexamethasone and ultraviolet B treatment.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”
In this study, researchers found that TSPyV T antigens can disrupt normal cell differentiation and proliferation in hairfollicles and interfollicular epidermis, possibly contributing to trichodysplasia spinulosa pathology.
2 citations
,
April 2019 in “Experimental Dermatology”
This study observed that applying a pulling force to hairfollicles led to significant compression of nuclei in certain cell layers and distinct collagen changes at different follicle depths.
Scientists have grown natural-looking hair from stem cells, potentially revolutionizing hair growth treatments. Concerns include cost, DHT resistance, and the need for future procedures.
The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.
SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.
Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hairfollicle regeneration, though skepticism about their effectiveness and timeline persists.