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GlossaryMonocyte Chemoattractant Protein-1 (CCL2)

signaling protein that attracts monocytes to inflammation sites

Monocyte Chemoattractant Protein-1 (MCP-1), also known as CCL2, is a signaling protein that plays a crucial role in the immune system by attracting monocytes, a type of white blood cell, to sites of inflammation or injury. This protein is important in the body's response to infection and tissue damage, but excessive MCP-1 activity can contribute to chronic inflammatory diseases.

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research Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

286 citations, June 2012 in “Nature Immunology”

Hair follicles help attract immune cells to the skin during stress.

research Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin

192 citations, March 2017 in “Cell host & microbe”

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

research The Role of the Microbiome in Scalp Hair Follicle Biology and Disease

73 citations, April 2019 in “Experimental Dermatology”

The scalp's microorganisms significantly affect hair health and disease.

research Single-Cell Transcriptomics Reveals a Senescence-Associated IL-6/CCR6 Axis Driving Radiodermatitis

9 citations, July 2022 in “EMBO molecular medicine”

Blocking certain immune signals can reduce skin damage from radiation therapy.

Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

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community Aromatase Upregulation along with DHT down regulation could possibly hold the cure

in Microneedling 7 upvotes 2 years ago

The post discusses the potential of upregulating aromatase to treat hair loss, suggesting that increasing CCL2 levels through Vitamin D or microneedling might help. The user questions why microneedling doesn't work for everyone, especially those with advanced hair loss.