Wound Healing: A Cellular Perspective

November 2018 in “ Physiological Reviews ”

Mélanie Rodrigues, Nina Kosaric, Clark A. Bonham, Geoffrey C. Gurtner

TLDR The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The 2019 document "Wound Healing: A Cellular Perspective" provided a comprehensive analysis of the cellular and molecular mechanisms involved in wound healing. It highlighted the roles of various cell types, including platelets, neutrophils, macrophages, mast cells, dendritic cells, T cells, fibroblasts, keratinocytes, and melanocytes, and their interactions during different stages of healing. The document discussed the importance of the wound microenvironment, growth factors, and the balance between matrix metalloproteinases and their inhibitors in tissue remodeling. It also addressed the challenges of chronic wounds, influenced by conditions like diabetes and aging, and the economic impact they have. Clinical studies on therapies such as OASIS, Alloderm, Epicel, Apligraf, Dermagraft, and Grafix were reviewed, showing varying degrees of effectiveness in healing wounds. The document underscored the need for more targeted therapies and the potential of single-cell technologies to advance the understanding of cellular heterogeneity and stem cell function in skin repair, which could lead to improved cell-based treatments for skin injuries.

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