Wound Healing: A Cellular Perspective

November 2018 in “ Physiological Reviews ”

Mélanie Rodrigues, Nina Kosaric, Clark A. Bonham, Geoffrey C. Gurtner

TLDR The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The 2019 document "Wound Healing: A Cellular Perspective" provided a comprehensive analysis of the cellular and molecular mechanisms involved in wound healing. It highlighted the roles of various cell types, including platelets, neutrophils, macrophages, mast cells, dendritic cells, T cells, fibroblasts, keratinocytes, and melanocytes, and their interactions during different stages of healing. The document discussed the importance of the wound microenvironment, growth factors, and the balance between matrix metalloproteinases and their inhibitors in tissue remodeling. It also addressed the challenges of chronic wounds, influenced by conditions like diabetes and aging, and the economic impact they have. Clinical studies on therapies such as OASIS, Alloderm, Epicel, Apligraf, Dermagraft, and Grafix were reviewed, showing varying degrees of effectiveness in healing wounds. The document underscored the need for more targeted therapies and the potential of single-cell technologies to advance the understanding of cellular heterogeneity and stem cell function in skin repair, which could lead to improved cell-based treatments for skin injuries.

View this study on journals.physiology.org →

Discuss this study in the Community →

Research cited in this study

20 / 20 results

research Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties

143 citations, May 2017 in “Nature cell biology”

Wounded skin cells can revert to stem cells and help heal.

research The Role of Macrophages in Skin Homeostasis

65 citations, February 2017 in “Pflügers Archiv - European Journal of Physiology”

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

research Regeneration of Fat Cells from Myofibroblasts During Wound Healing

408 citations, January 2017 in “Science”

Some wound-healing cells can turn into fat cells around new hair growth in mice.

research Scarless Wound Healing: Finding the Right Cells and Signals

132 citations, June 2016 in “Cell and Tissue Research”

The right cells and signals can potentially lead to scarless wound healing, with a mix of natural and external wound healing controllers possibly being the best way to achieve this.

research Epithelial Skin Biology: Stem Cells and Epidermal Homeostasis

118 citations, January 2016 in “Current Topics in Developmental Biology”

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

research Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

87 citations, January 2016 in “Development”

Blocking β-catenin in skin cells improves hair growth during wound healing.

research Progenitor Cell Dysfunctions Underlie Some Diabetic Complications

46 citations, June 2015 in “American Journal Of Pathology”

Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

479 citations, June 2014 in “Science”

Epithelial stem cells can adapt and help in tissue repair and regeneration.

research Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche

133 citations, September 2013 in “Nature Reviews Molecular Cell Biology”

Different types of stem cells and their environments are key to skin repair and maintenance.

research Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing

238 citations, March 2013 in “Development”

Fat cells help recruit healing cells and build skin structure during wound healing.

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

161 citations, August 2012 in “Seminars in cell & developmental biology”

Hair growth and development are controlled by specific signaling pathways.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations, June 2012 in “Nature”

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

research Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin

128 citations, October 2011 in “Development”

Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations, June 2011 in “Cell”

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations, May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Ferreting Out Stem Cells From Their Niches

80 citations, May 2011 in “Nature Cell Biology”

New methods have greatly improved our understanding of stem cell behavior and roles in the body.

research Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins

106 citations, September 2010 in “Stem cells”

Skin-derived precursors in hair follicles come from different origins but function similarly.

research Epithelial Stem Cells: Turning Over New Leaves

508 citations, February 2007 in “Cell”

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations, August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

Related Community Posts Join

6 / 77 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Does anyone else have experience with Patented Growth Factors (PGF) Treatments / experiences with depression on Fin/Min/Dut?

in Treatment 1 upvotes 1 month ago

The user is exploring hair loss treatments, including Patented Growth Factors (PGF) and a serum with Copper Peptide, Ceramides, Amino Acids, and Caffeine, while expressing concerns about the cost and effectiveness of PGF. They are also considering starting finasteride due to doubts about PGF's long-term viability and are seeking experiences from others who have used these treatments alongside antidepressants.

community 5 months of Hims Topical Finasteride & Minoxidil Spray. It’s not as impressive as other progress pics, but this is huge for me.

in Progress Pictures 530 upvotes 1 year ago

A user shared their positive experience with Hims Topical Finasteride & Minoxidil Spray for hair loss over 5 months, noting an improvement in their receding hairline without taking finasteride pills. Their daily routine includes applying the spray after showering and then styling their hair.

community What about botox injections on the scalp?

in Research/Science 6 upvotes 1 year ago

Botox injections on the scalp may help with hair loss, as one small study showed improvement in 8 out of 10 subjects. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community If you can give one advice to your younger self then what that would be?

in Research/Science 2677 upvotes 4 months ago

Users discussed hair loss treatments, specifically minoxidil and finasteride. They shared personal experiences and advice on starting these treatments early.

community Is microneedling supposed to be a blood bath? 1mm dermastamp

in Microneedling 41 upvotes 8 months ago

The conversation is about someone experiencing a lot of bleeding from using a 1.0mm microneedling device for hair loss treatment and asking if it's normal. Various users suggest that the bleeding is excessive and recommend using shorter needles or less pressure, while others share their own microneedling practices with different needle lengths and no bleeding.

Similar Research

6 / 1000+ results

research Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation

18 citations, November 2020 in “Frontiers in Cell and Developmental Biology”

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

research The Dynamics of the Skin’s Immune System

306 citations, April 2019 in “International Journal of Molecular Sciences”

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

research Immune Cell Regulation of the Hair Cycle

27 citations, January 2020 in “Experimental Dermatology”

Immune cells affect hair growth and could lead to new hair loss treatments.

research Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models

5 citations, February 2022 in “International Journal of Molecular Sciences”

Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.

research Interrelation of Immunity and Tissue Repair or Regeneration

252 citations, April 2009 in “Seminars in Cell & Developmental Biology”

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

research Molecular Regulation and Cellular Heterogeneity in Skin Repair and Hair Follicle Regeneration

January 2019

Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.