Scarless Wound Healing: Finding the Right Cells and Signals

    June 2016 in “ Cell and Tissue Research ”
    Tripp Leavitt, Michael S. Hu, Clement D. Marshall … Michael T. Longaker
    Studysummary This review discusses recent advancements in scar reduction techniques, highlighting promising therapeutic targets and the role of Wnt/β-catenin signaling in promoting scarless wound healing, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 14

    1. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    2. Inhibition of Wnt/β-Catenin Pathway Promotes Regenerative Repair of Cutaneous and Cartilage Injury The FASEB Journal · 2015
    3. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing Organogenesis · 2015
    4. Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately Stem Cell Research & Therapy · 2015
    5. Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart PLOS ONE · 2015
    6. Improved Cutaneous Wound Healing After Intraperitoneal Injection of Alpha-Melanocyte-Stimulating Hormone Experimental Dermatology · 2014
    7. Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth PloS one · 2014
    8. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    9. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    10. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    11. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    12. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    13. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    14. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005

    Related research 1

    1. Scarless Wound Healing: Finding the Right Cells and Signals Cell and Tissue Research · 2016