TLDR Wnt signaling is crucial for skin wound healing and reducing scars.
The study reviewed the role of Wnt signaling in cutaneous wound healing, emphasizing its activation by wounding and its involvement in inflammation, cell proliferation, and stem cell mobilization. Wnt signaling was crucial for skin architecture regeneration, influencing cell differentiation and proliferation necessary for tissue repair. The research suggested that enhancing endogenous Wnt pathways could improve cutaneous regeneration and reduce scar formation. It was noted that Wnt-responsive interfollicular stem cells, rather than hair follicle stem cells, were responsible for new hair follicle formation during wound healing. Elevated β-catenin levels were essential for successful wound repair but could cause excessive fibrosis if prolonged. The study highlighted the potential of adult stem cells in therapies and the need for targeted Wnt signaling to avoid adverse effects like cancer.
Cited in this study
8 / 8 results
39 citations
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November 2013 in “Plastic and Reconstructive Surgery” Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.
237 citations
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June 2013 in “Nature Medicine” A protein from certain immune cells is key for new hair growth after skin injury in mice.
64 citations
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June 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Human stem cells can help form hair follicles in mice.
170 citations
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January 2013 in “Journal of Investigative Dermatology” Wnt ligands are crucial for hair growth and repair.
89 citations
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January 2009 in “Advances in Clinical Chemistry” Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.
72 citations
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April 2008 in “Organogenesis” Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.
829 citations
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May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
788 citations
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
October 2016 Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.