Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing

    October 2013 in “ PLoS ONE ”
    Jemima Whyte, Andrew A. Smith, Бо Лю … Jill A. Helms
    Studysummary This study found that amplifying Wnt signaling, either genetically or through topical application of liposomal Wnt3a, improved skin wound healing in a mouse model.
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    Research cited in this study 8

    1. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    2. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    3. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    4. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    5. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    6. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    7. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    8. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999