Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

May 2007 in “ Nature ”

Mayumi Ito, Zaixin Yang, Thomas Andl, Chunhua Cui, Noori Kim, Sarah E. Millar, George Cotsarelis

Wnt signaling hair follicle regeneration hair follicle neogenesis non-hair-follicle bulge cells embryonic follicle development

TLDR Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

This 2007 study found that hair follicles can be regenerated in adult mice skin after wounding through a process similar to embryonic follicle development. The study suggests that non-hair-follicle bulge cells were the primary source of regenerated follicles, and that Wnt signaling is necessary for hair follicle neogenesis following wounding. The study provides insights into the mechanisms of hair follicle regeneration and could have implications for the treatment of hair loss in humans.

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Research cited in this study

11 / 11 results

research Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing

159 citations , January 2006 in “BMC Cell Biology”

Wnt signaling can improve skin healing by promoting epithelial growth.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations , January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis

293 citations , September 2004 in “Development”

WNT signaling is crucial for starting mammary gland development.

research Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors

335 citations , March 2004 in “Development”

Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research WNT Signaling in the Control of Hair Growth and Structure

271 citations , March 1999 in “Developmental biology”

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development

318 citations , October 1998 in “The Journal of Cell Biology”

Keratin 17 is important for skin development and may help define skin cell types.

research The Formation of Vellus Hair Follicles from Human Adult Epidermis

73 citations , July 1956 in “Journal of Investigative Dermatology”

Adult human skin can grow new fine hair follicles after a deep exfoliation treatment.

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