Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

    May 2007 in “ Nature ”
    Mayumi Ito, Zaixin Yang, Thomas Andl … George Cotsarelis
    Studysummary Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
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    Research cited in this study 11

    1. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing BMC Cell Biology · 2006
    2. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    3. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    4. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    5. Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis Development · 2004
    6. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    7. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    8. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    9. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    10. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    11. The Formation of Vellus Hair Follicles from Human Adult Epidermis Journal of Investigative Dermatology · 1956

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    5. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    6. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    7. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005