Liposomal Packaging Generates Wnt Protein with In Vivo Biological Activity

    August 2008 in “ PLOS ONE ”
    Nathan T. Morrell, Philipp Leucht, Ludan Zhao, Jae-Beom Kim, Derk ten Berge, Karthikeyan Ponnusamy, Antoine L. Carre, Henryk Dudek, Marie Zachlederova, Michael McElhaney, Shirley A. Brunton, Janet L. Gunzner, Marinella Callow, Paul Polakis, Mike Costa, Xiaoyan M. Zhang, Jill A. Helms, Roel Nusse
    Image of study
    TLDR Wnt3a protein, when packed in liposomal vesicles, can stimulate hair growth and could potentially treat conditions like hair loss.
    The 2008 study "Liposomal Packaging Generates Wnt Protein with In Vivo Biological Activity" demonstrated that Wnt3a protein, when packaged into liposomal vesicles, retained its biological activity and could be delivered to cellular receptors in vivo. This led to the activation of Wnt signaling pathways, which stimulated hair follicle growth and cycling. This suggested potential applications in treating conditions like alopecia. However, the study did not specify the number of subjects involved. The researchers also found that Wnt antagonists, which were effective against purified protein, were ineffective against Wnt secreted from cells and liposomal Wnt, indicating that liposomal packaging mimics the method by which Wnts are normally secreted from cells.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    1 / 1 results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  53 upvotes 2 months ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

    Similar Research

    5 / 940 results