TLDR Wnt3a protein, when packed in liposomal vesicles, can stimulate hair growth and could potentially treat conditions like hair loss.
The 2008 study "Liposomal Packaging Generates Wnt Protein with In Vivo Biological Activity" demonstrated that Wnt3a protein, when packaged into liposomal vesicles, retained its biological activity and could be delivered to cellular receptors in vivo. This led to the activation of Wnt signaling pathways, which stimulated hair follicle growth and cycling. This suggested potential applications in treating conditions like alopecia. However, the study did not specify the number of subjects involved. The researchers also found that Wnt antagonists, which were effective against purified protein, were ineffective against Wnt secreted from cells and liposomal Wnt, indicating that liposomal packaging mimics the method by which Wnts are normally secreted from cells.
220 citations
,
August 2007 in “Journal of Bone and Mineral Research” The study investigated the role of Wnt signaling in bone regeneration using TOPgal reporter mice. It was found that Wnt signaling was activated at injury sites, and inhibiting Wnt through Dkk1 expression reduced bone regeneration by 84%. Conversely, a mutation in the Lrp5 Wnt co-receptor, which activates Wnt signaling, resulted in delayed bone regeneration due to prolonged proliferation and delayed differentiation of osteoprogenitor cells. These findings highlighted the critical role of Wnt signaling in bone regeneration and suggested potential therapeutic approaches for enhancing bone formation in clinical settings.
829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
Natural products may help treat hair loss by promoting hair growth with fewer side effects.
31 citations
,
June 2021 in “Biomedicine & Pharmacotherapy” Liposomal honokiol helps hair regrowth by activating certain pathways and reducing specific proteins.
21 citations
,
May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
47 citations
,
July 2013 in “Pharmacological Reviews” Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
2 citations
,
January 2022 in “Oxidative Medicine and Cellular Longevity” Exosomes from dermal papilla cells help hair follicle stem cells grow and survive.
