Exosomes Derived From Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation Through The Wnt3a/Beta-Catenin Signaling Pathway

January 2022 in “ Oxidative Medicine and Cellular Longevity ”

Jiali Li, Bohao Zhao, Yingying Dai, Xiyu Zhang, Yang Chen, Xinsheng Wu

exosomes dermal papilla cells hair follicle stem cells Wnt3a β-catenin signaling pathway PCNA protein apoptosis Wnt/β-catenin pathway DPC-Exos HFSC Wnt signaling

Studysummary This study suggests that exosomes from dermal papilla cells can regulate hair follicle stem cell proliferation via the Wnt3a/β-catenin signaling pathway, potentially informing treatment for human hair problems.

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The study demonstrates that exosomes derived from dermal papilla cells (DPC-Exos) enhance hair follicle stem cell (HFSC) proliferation and inhibit apoptosis through the Wnt3a/β-catenin signaling pathway. Using a coculture system, it was observed that DPCs promote HFSC proliferation, indicated by increased PCNA protein levels. The overexpression of Wnt3a in DPC-Exos upregulated downstream genes in the Wnt/β-catenin pathway, enhancing HFSC proliferation and reducing apoptosis. These findings suggest potential applications in molecular breeding of Angora rabbits and treatments for human hair disorders.

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