TLDR Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.
The 2003 workshop on Hair Follicle Stem Cells revealed that follicular epithelial stem cells, located in the bulge region of developing human fetal hair follicles, are multipotent and can generate all hair cell types, the epidermis, and sebaceous glands. These stem cells play a crucial role in the hair cycle, transitioning from quiescent to proliferative states during early anagen, influenced by signals from the follicular papilla. Transplantation studies in mice demonstrated that bulge cells could migrate and differentiate into various cell types within the follicle and epidermis, supporting the concept of a pilosebaceous epithelial unit (PSU). The findings underscored the importance of further research to understand the regulatory signals for stem cell division and differentiation, with vibrissa follicles serving as excellent models for studying these processes.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
29 citations,
April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” ICAM-1 helps regulate hair growth cycles and skin remodeling.
7 citations,
May 1995 in “The journal of investigative dermatology/Journal of investigative dermatology” 130 citations,
January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.
745 citations,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
21 citations,
May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
April 2016 in “Journal of Investigative Dermatology” Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.