Nature-Derived Lignan Compound VB-1 Exerts Hair Growth-Promoting Effects by Augmenting Wnt/β-Catenin Signaling in Human Dermal Papilla Cells

May 2018 in “ PeerJ ”

Jieshu Luo, Mengting Chen, Yingzi Liu, Hongfu Xie, Jian Yuan, Yingjun Zhou, Jinsong Ding, Zhili Deng, Ji Li

VB-1 lignan compound human dermal papilla cells hDPCs Wnt/β-catenin signaling hair shaft elongation alopecia hair growth hair follicles hair loss

TLDR VB-1, a natural compound, may promote hair growth by enhancing a key cell growth pathway.

The document from May 8, 2018, detailed a study on the hair growth-promoting effects of a nature-derived lignan compound called VB-1. The study found that VB-1 significantly promoted the proliferation of human dermal papilla cells (hDPCs), which are crucial for hair growth regulation. VB-1 was also found to activate Wnt/β-catenin signaling in these cells, a pathway essential for hair growth. Additionally, VB-1 facilitated hair shaft elongation in cultured human hair follicles, but these effects were concentration-dependent, with high concentrations of VB-1 inhibiting cell growth. The study concluded that VB-1 has potential as a new therapy for alopecia treatment, but further studies are required to verify these results and determine practical dosing.

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