Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells

    May 2013 in “ Journal of Investigative Dermatology ”
    Ji Li, Ting Jiang, Cheng Ming Chuong
    Studysummary This review explores the molecular processes behind hair follicle stem cell activation and suggests new potential targets for designing therapies for various types of alopecia, but it reports no clinical results.
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    Research cited in this study 12

    1. Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    2. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012
    3. Physiological Regeneration of Skin Appendages and Implications for Regenerative Medicine Physiology · 2012
    4. Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia Journal of Dermatological Science · 2012
    5. A Family Business: Stem Cell Progeny Join the Niche to Regulate Homeostasis Nature Reviews Molecular Cell Biology · 2012
    6. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    7. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    8. EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair Genes & Development · 2011
    9. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    10. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010
    11. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    12. The Biology of Hair Follicles The New England Journal of Medicine · 1999

    Related research 4

    1. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    2. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    3. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    4. Skin and Hair: Models for Exploring Organ Regeneration Human Molecular Genetics · 2008