Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations
MED1 keratinocytes hair-cycling defects epidermal alterations keratinocyte proliferation hair follicle anagen phase hyperplasia hair differentiation Hedgehog signaling pathway BMP signaling pathway hair differentiation genes hyper-proliferative skin diseases hair growth cycle skin changes cell proliferation hair growth phase skin thickening hair growth Hedgehog pathway bone morphogenetic protein pathway skin diseases
TLDR Deleting MED1 in skin cells causes hair loss and skin changes.
The study demonstrated that the ablation of the coactivator MED1 in keratinocytes led to significant hair-cycling defects and epidermal alterations in mice. MED1 deletion caused increased keratinocyte proliferation, abnormal activation of the hair follicle anagen phase, hyperplasia, and incomplete hair differentiation. The null mice showed accelerated hair follicle progression but impaired terminal differentiation, with altered expression of hair differentiation genes and signaling pathways such as Hedgehog and BMP. These findings highlighted the critical role of MED1 in maintaining hair differentiation and skin integrity, providing insights into potential therapeutic targets for hair loss and hyper-proliferative skin diseases.
