Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

November 2005 in “ Endocrinology ”

Zhongjian Xie, Sam K. C. Chang, Yuko Oda, Daniel D. Bikle

Hairless protein Vitamin D Receptor VDR human keratinocytes corepressor VDR target genes hair growth skin health hair follicle function skin homeostasis HR gene hair loss disorders alopecia HR protein hair loss

TLDR Hairless protein can block vitamin D activation in skin cells.

The study concluded that the Hairless (HR) protein suppressed the transactivation activity of the Vitamin D Receptor (VDR) in human keratinocytes by acting as a corepressor. This suppression inhibited the expression of VDR target genes, which are crucial for hair growth and skin health. The interaction between HR and VDR was shown to be significant in maintaining proper hair follicle function and skin homeostasis, suggesting that mutations in the HR gene could lead to hair loss disorders such as alopecia.

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Research cited in this study

9 / 9 results

research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice

40 citations , October 2002 in “Endocrinology”

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.

Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues Alopecia in Vitamin D Receptor Null Mice

research Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues Alopecia in Vitamin D Receptor Null Mice

57 citations , April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D receptor is crucial for starting hair growth after birth.

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

180 citations , January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is crucial for normal skin and hair growth.

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations , September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

research Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans

126 citations , October 1998 in “Experimental Dermatology”

The hr gene is crucial for skin and hair health, with mutations causing hair disorders.

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

519 citations , October 1998 in “Endocrinology”

Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.

research Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs

53 citations , October 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical calcitriol-analogs can reduce hair loss caused by chemotherapy.

Related Research

3 / 3 results

Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

Research cited in this study

research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

research Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice

research Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues Alopecia in Vitamin D Receptor Null Mice

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

research Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

research Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs

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