Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

November 2005 in “ Endocrinology ”

Zhongjian Xie, Sam K. C. Chang, Yuko Oda, Daniel D. Bikle

Hairless protein Vitamin D Receptor VDR human keratinocytes corepressor VDR target genes hair growth skin health hair follicle function skin homeostasis HR gene hair loss disorders alopecia HR protein hair loss

Studysummary This study found that Hairless (Hr) acts as a corepressor of the vitamin D receptor (VDR) in human keratinocytes, blocking the action of vitamin D on keratinocyte differentiation.

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