Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

November 2005 in “ Endocrinology ”

Zhongjian Xie, Sam K. C. Chang, Yuko Oda, Daniel D. Bikle

Hairless protein Vitamin D Receptor VDR human keratinocytes corepressor VDR target genes hair growth skin health hair follicle function skin homeostasis HR gene hair loss disorders alopecia HR protein hair loss

TLDR Hairless protein can block vitamin D activation in skin cells.

The study concluded that the Hairless (HR) protein suppressed the transactivation activity of the Vitamin D Receptor (VDR) in human keratinocytes by acting as a corepressor. This suppression inhibited the expression of VDR target genes, which are crucial for hair growth and skin health. The interaction between HR and VDR was shown to be significant in maintaining proper hair follicle function and skin homeostasis, suggesting that mutations in the HR gene could lead to hair loss disorders such as alopecia.

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Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

Research cited in this study

research Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle

research Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis

research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

research Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice

research Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues Alopecia in Vitamin D Receptor Null Mice

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

research Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

research Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice

research Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice

research A Novel Missense Mutation (C622G) in the Zinc-Finger Domain of the Human Hairless Gene Associated with Congenital Atrichia with Papular Lesions

research Novel Hairless Mutations in Two Kindreds with Autosomal Recessive Papular Atrichia

research A Homozygous Nonsense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia

research The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation

research A Missense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia in a Family of Irish Travellers

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

research Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans

research Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs

research Alopecia Universalis Associated With a Mutation in the Human Hairless Gene

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