Novel Mechanisms for the Vitamin D Receptor in the Skin and in Skin Cancer

October 2014 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

Bikle, Daniel D., Oda Yuko, Tu, Chia-Ling, Jiang Yan

vitamin D receptor VDR epidermal differentiation hair follicle cycling 1,25(OH)2D Med 1 SRC3 calcium sensing receptor CaSR vitamin D calcitriol

TLDR Vitamin D receptor helps prevent skin cancer and supports skin health.

The study explored the role of the vitamin D receptor (VDR) in skin processes, highlighting its involvement in epidermal differentiation and hair follicle cycling (HFC), both with and without its ligand 1,25(OH)2D. VDR was found to regulate these processes through various coregulators, such as Med 1 and SRC3, and its absence led to increased tumor formation in mice. The study also noted that VDR, in conjunction with the calcium sensing receptor (CaSR), played a crucial role in preventing spontaneous skin tumors. The research emphasized that VDR's functions in the skin were mediated by both 1,25(OH)2D dependent and independent mechanisms, and its disruption could lead to cancer formation.

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