25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis
25 Hydroxyvitamin D 1 α-Hydroxylase epidermal differentiation permeability barrier homeostasis involucrin filaggrin loricrin transepidermal water loss TEWL calcium gradient lamellar body secretion keratinocyte differentiation 1,25-dihydroxyvitamin D 1,25(OH)2D vitamin D skin barrier water loss calcium keratin
Studysummary This study found that mice lacking the 1αOHase enzyme, which is responsible for producing a key vitamin D metabolite, showed impaired epidermal differentiation and delayed recovery of skin barrier function after disruption.
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