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GlossaryLoricrin

protein crucial for skin's outermost layer integrity and resilience

Loricrin is a protein that plays a crucial role in the formation of the skin's outermost layer, the stratum corneum. It is a major component of the cornified cell envelope, which provides a barrier to protect against environmental damage and water loss. This protein is essential for maintaining the skin's integrity and resilience.

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research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

research Thyroid-Stimulating Hormone: A Novel, Locally Produced Modulator of Human Epidermal Functions, Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones

105 citations , February 2010 in “Endocrinology”

The skin produces and responds to thyroid-stimulating hormone, which is controlled by other thyroid-related hormones.

research Biochemical Evidence That Small Proline-Rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes

99 citations , May 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Small proline-rich proteins and trichohyalin help make epithelial tissues tougher and more flexible.

research A Keratin Scaffold Regulates Epidermal Barrier Formation, Mitochondrial Lipid Composition, And Activity

98 citations , December 2015 in “The Journal of Cell Biology”

Keratin is crucial for skin barrier formation and affects mitochondrial function.

research Noggin Overexpression Inhibits Eyelid Opening by Altering Epidermal Apoptosis and Differentiation

65 citations , June 2003 in “EMBO journal”

Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.

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