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    Glossary Loricrin

    protein crucial for skin's outermost layer integrity and resilience

    Loricrin is a protein that plays a crucial role in the formation of the skin's outermost layer, the stratum corneum. It is a major component of the cornified cell envelope, which provides a barrier to protect against environmental damage and water loss. This protein is essential for maintaining the skin's integrity and resilience.

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    Research 30 of 462

    1. Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth 2002 · 180 citations
    2. 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis 2004 · 140 citations
    3. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001 · 130 citations
    4. Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones Endocrinology · 2010 · 105 citations
    5. Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes 1998 · 99 citations
    6. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    7. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005 · 77 citations
    8. Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation EMBO journal · 2003 · 65 citations
    9. Organization and Expression of Hair Follicle Genes. 1993 · 48 citations
    10. Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes Experimental Dermatology · 2019 · 44 citations
    11. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    12. Harlequin ichthyosis (ichq): a juvenile lethal mouse mutation with ichthyosiform dermatitis. PubMed · 1997 · 27 citations
    13. Colocalization of Cystatin M/E and its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail 2008 · 22 citations
    14. Distribution of keratin and associated proteins in the epidermis of monotreme, marsupial, and placental mammals Journal of Morphology · 2003 · 21 citations
    15. The role of cathepsin E in terminal differentiation of keratinocytes Biological Chemistry · 2011 · 15 citations
    16. Twist1 is required for the development of UVB‐induced squamous cell carcinoma Molecular Carcinogenesis · 2021 · 11 citations
    17. Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy International journal of trichology · 2010 · 10 citations
    18. “Structural imprinting” of the cutaneous immune effector function Tissue Barriers · 2020 · 4 citations
    19. Formation of the cornified envelope Experimental dermatology · 2005 · 3 citations
    20. The germinative epithelium of sheep vibrissae and wool follicles has extensive proliferative potential but is dependent on the dermal papilla International journal of trichology · 2012 · 1 citations
    21. Transdermal Delivery of Valproate–Choline Ionic Liquid Induces Hair Regrowth ACS Applied Materials & Interfaces · 2025
    22. The Role of EAAT4 in Epidermal Differentiation and Calcium Homeostasis during Aging 2023
    23. LB1077 Cutaneous responses to systemic iron: A potential role for epidermal turnover in mammalian iron excretion Journal of Investigative Dermatology · 2019
    24. 875 A novel animal model of Desmoglein 1 (Dsg1) deficiency reveals an essential role for Dsg1 in epidermal barrier formation Journal of Investigative Dermatology · 2018
    25. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proceedings of the National Academy of Sciences · 2001 · 201 citations
    26. Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System Evidence-based Complementary and Alternative Medicine · 2020 · 2 citations
    27. The role of Twist1 in UVB-induced skin carcinogenesis 2020
    28. 316 Specialized ribosomes in human dermal fibroblast senescence Journal of Investigative Dermatology · 2019
    29. 313 Different polyamine levels in the vertex and occipital hair of pattern hair loss patients Journal of Investigative Dermatology · 2019
    30. α3β1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis Journal of Cell Science · 2003 · 45 citations