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GlossaryInvolucrin

protein in skin cells aiding barrier formation

Involucrin is a protein found in the upper layers of the skin, specifically in the cells of the epidermis. It plays a crucial role in forming the protective barrier of the skin by contributing to the structure of the cornified envelope, which helps protect against environmental damage and water loss.

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research Regulation of Involucrin Gene Expression

138 citations, June 2004 in “Journal of Investigative Dermatology”

Involucrin gene expression is controlled by specific proteins and signaling pathways.

research Ultrastructural Immunolocalization of Involucrin in the Medulla and Inner Root Sheath of Human Hair

7 citations, December 2011 in “Annals of anatomy”

Involucrin helps strengthen the inner parts of human hair.

Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

research Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

3 citations, July 2011 in “Folia Histochemica et Cytobiologica”

Calcium reduces involucrin in rat hair bulbs but doesn't affect filaggrin and Kdap.

research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations, April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

research Noggin Overexpression Inhibits Eyelid Opening by Altering Epidermal Apoptosis and Differentiation

65 citations, June 2003 in “EMBO journal”

Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.

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