Analysis of the Relation Between Alopecia and Resistance to 1,25-Dihydroxyvitamin D

    October 1986 in “ Clinical Endocrinology ”
    S J Marx, M. M. Bliziotes, M. Nanes, S J Marx, M. M. Bliziotes, M. Nanes
    TLDR Alopecia indicates more severe resistance to 1,25-dihydroxyvitamin D.
    The study analyzed the relationship between alopecia and hereditary resistance to 1,25-dihydroxyvitamin D (1,25(OH)2D) in 30 kindreds. It found that alopecia was associated with more severe resistance, as indicated by an earlier age of diagnosis (0.9 years vs. 3.3 years) and a lower calcaemic response to calciferol therapy. During treatment, patients with alopecia had lower serum calcium levels but higher serum 1,25(OH)2D levels compared to those with normal hair. Additionally, cells from most kindreds with alopecia showed no response to 1,25(OH)2D3 in terms of 24-hydroxylase activity, unlike those from kindreds with normal hair. The findings suggested that alopecia in these cases reflected more severe resistance to 1,25(OH)2D.
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