New Aspects of Vitamin D Metabolism and Action: Addressing the Skin as Source and Target

    February 2020 in “ Nature Reviews Endocrinology ”
    Daniel D. Bikle, Sylvia Christakos
    Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

    We don't know much about this study yet.

    Read the full study on nature.com →
    Discuss this study in the Community →

    Research cited in this study 42

    1. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    2. Increased Prevalence of Vitamin D Deficiency in Patients with Alopecia Areata: A Systematic Review and Meta-Analysis JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2018
    3. Correlation of Vitamin D and Vitamin D Receptor Expression in Patients with Alopecia Areata: A Clinical Paradigm International Journal of Dermatology · 2017
    4. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization Endocrinology · 2017
    5. The Transient Role of Calcium and Vitamin D During the Developmental Hair Follicle Cycle Journal of Investigative Dermatology · 2016
    6. The Vitamin D Receptor Functions as a Transcription Regulator in the Absence of 1,25-Dihydroxyvitamin D3 The Journal of Steroid Biochemistry and Molecular Biology · 2015
    7. Novel Mechanisms for the Vitamin D Receptor in the Skin and in Skin Cancer The Journal of Steroid Biochemistry and Molecular Biology · 2014
    8. The Vitamin D Receptor Is Required for Activation of CWnt and Hedgehog Signaling in Keratinocytes Molecular Endocrinology · 2014
    9. A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia Endocrinology · 2014
    10. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014
    11. Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets BoneKEy Reports · 2014
    12. Reciprocal Role of Vitamin D Receptor on β-Catenin Regulated Keratinocyte Proliferation and Differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013
    13. Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-Beta Signaling During the Inflammatory Response to Cutaneous Injury Endocrinology · 2012
    14. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    15. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    16. The Hair Cycle and Vitamin D Receptor Archives of Biochemistry and Biophysics · 2011
    17. Vitamin D and the Skin: Physiology and Pathophysiology Reviews in endocrine and metabolic disorders · 2011
    18. Overexpression of Hedgehog Signaling Is Associated With Epidermal Tumor Formation in Vitamin D Receptor-Null Mice Journal of Investigative Dermatology · 2011
    19. Vitamin D Metabolism and Function in the Skin Molecular and cellular endocrinology · 2011
    20. Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor Journal of Biological Chemistry · 2011
    21. Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice Journal of Cellular Physiology · 2010
    22. Analysis of Hairless Corepressor Mutants to Characterize Molecular Cooperation with the Vitamin D Receptor in Promoting the Mammalian Hair Cycle Journal of Cellular Biochemistry · 2010
    23. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    24. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    25. The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    26. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    27. Role of β-Catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer Cold Spring Harbor Symposia on Quantitative Biology · 2008
    28. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    29. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    30. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005
    31. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    32. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    33. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    34. Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    35. Extrarenal Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase The Journal of Clinical Endocrinology & Metabolism · 2001
    36. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice Endocrinology · 2000
    37. Analysis of 1,25-Dihydroxyvitamin D3 Receptors in Basal Cell Carcinomas ˜The œAmerican journal of pathology · 1999
    38. The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation American Journal Of Pathology · 1999
    39. Alopecia Universalis Associated With a Mutation in the Human Hairless Gene Science · 1998
    40. Analysis of the Relation Between Alopecia and Resistance to 1,25-Dihydroxyvitamin D Clinical Endocrinology · 1986
    41. Calcitriol-Resistant Rickets With Alopecia Archives of Dermatology · 1985
    42. Topographical and Developmental Studies on Target Sites of 1,25 (OH)₂ Vitamin D₃ in Skin Cell & tissue research/Cell and tissue research · 1984