New Aspects of Vitamin D Metabolism and Action: Addressing the Skin as Source and Target
February 2020
in “
Nature Reviews Endocrinology
”
Research cited in this study
42 / 42 results
research Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair
The vitamin D receptor is essential for skin stem cells to grow, move, and become different cell types needed for skin healing.
research Increased Prevalence of Vitamin D Deficiency in Patients with Alopecia Areata: A Systematic Review and Meta-Analysis
People with alopecia areata often have lower vitamin D levels and are more likely to be deficient in it.
research Correlation of Vitamin D and Vitamin D Receptor Expression in Patients with Alopecia Areata: A Clinical Paradigm
People with alopecia areata often have lower vitamin D levels, which are linked to more severe and longer-lasting hair loss, but vitamin D receptor levels in the skin don't show the same pattern and don't predict treatment success.
research Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization
Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.
research The Transient Role of Calcium and Vitamin D During the Developmental Hair Follicle Cycle
Vitamin D and calcium are essential for normal hair growth.
research The Vitamin D Receptor Functions as a Transcription Regulator in the Absence of 1,25-Dihydroxyvitamin D3
The vitamin D receptor can regulate genes and affect hair and hormone levels without its usual activator.
research Novel Mechanisms for the Vitamin D Receptor in the Skin and in Skin Cancer
Vitamin D receptor helps prevent skin cancer and supports skin health.
research The Vitamin D Receptor Is Required for Activation of CWnt and Hedgehog Signaling in Keratinocytes
Vitamin D receptor is essential for hair growth signaling.
research A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia
Researchers created a mouse model of a type of rickets that does not cause hair loss.
research Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin
The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.
research Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets
Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.
research Reciprocal Role of Vitamin D Receptor on β-Catenin Regulated Keratinocyte Proliferation and Differentiation
Vitamin D receptor helps control skin cell growth and hair development.
research Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-Beta Signaling During the Inflammatory Response to Cutaneous Injury
Vitamin D receptor is essential for proper skin healing after injury.
research Epithelial Stem Cells And Implications For Wound Repair
Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.
research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations
Deleting MED1 in skin cells causes hair loss and skin changes.
research The Hair Cycle and Vitamin D Receptor
Vitamin D receptor is essential for healthy hair growth.
research Vitamin D and the Skin: Physiology and Pathophysiology
Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.
research Overexpression of Hedgehog Signaling Is Associated With Epidermal Tumor Formation in Vitamin D Receptor-Null Mice
research Vitamin D Metabolism and Function in the Skin
Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor
LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.
research Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice
Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.
research Analysis of Hairless Corepressor Mutants to Characterize Molecular Cooperation with the Vitamin D Receptor in Promoting the Mammalian Hair Cycle
Certain mutations in the hairless protein disrupt its ability to regulate the hair cycle.
research The Hair Follicle as a Dynamic Mini-Organ
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
research Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis
Mice without the vitamin D receptor are more prone to UV-induced skin tumors.
research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment
Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.
research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis
Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.
research Role of β-Catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer
Beta-catenin is crucial for skin cell growth, development, and cancer formation.
research Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function
Vitamin D receptor is crucial for normal hair growth and preventing hair loss.
research Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse
Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.
research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes
Hairless protein can block vitamin D activation in skin cells.
research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling
Vitamin D receptor and hairless protein are essential for hair growth.
research Molecular Mechanisms Regulating Hair Follicle Development
Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth
Vitamin D Receptor is crucial for normal skin and hair growth.
research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene
Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.
research Extrarenal Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase
The enzyme for activating vitamin D is found in many body tissues, not just the kidneys.
research Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice
Alopecia in VDR knockout mice is due to a defect in hair cycle initiation, not keratinocyte issues.
research Analysis of 1,25-Dihydroxyvitamin D3 Receptors in Basal Cell Carcinomas
Basal cell carcinomas have much higher levels of Vitamin D3 receptors compared to healthy skin.
research The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation
research Alopecia Universalis Associated With a Mutation in the Human Hairless Gene
A mutation in the human hairless gene causes alopecia universalis.
research Analysis of the Relation Between Alopecia and Resistance to 1,25-Dihydroxyvitamin D
Alopecia indicates more severe resistance to 1,25-dihydroxyvitamin D.
research Calcitriol-Resistant Rickets With Alopecia
Calcitriol-resistant rickets is an inherited disorder that affects hair growth and causes hair loss.
research Topographical and Developmental Studies on Target Sites of 1,25 (OH)₂ Vitamin D₃ in Skin
Vitamin D3 affects cell differentiation in specific skin areas.