Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

    September 2003 in “ Journal of Biological Chemistry ”
    Jui‐Cheng Hsieh, Jeanne M. Sisk, Peter W. Jurutka … Catherine C. Thompson
    Studysummary This study found that the hairless gene product (Hr) suppresses VDR-mediated gene activation by directly interacting with the vitamin D receptor, potentially affecting hair follicle function.
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    Research cited in this study 9

    1. The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor Genes & Development · 2001
    2. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    3. Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    4. Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice Journal of Clinical Investigation · 2001
    5. Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis Nature · 2000
    6. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    7. Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans Experimental Dermatology · 1998
    8. The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed Journal of bone and mineral research · 1998
    9. Alopecia Universalis Associated With a Mutation in the Human Hairless Gene Science · 1998