TLDR The hr gene is crucial for skin and hair health, with mutations causing hair disorders.
The document discussed the hairless (hr) gene in laboratory rodents and humans, highlighting its role in skin physiology and hair follicle biology. Hairless and rhino mouse mutants served as models for studying skin-related aspects, but their primary defect, hairlessness, was often overlooked. The identification of the human homolog of the hr gene on Chromosome 8p12 linked it to a congenital hair disorder in humans, similar to hairless mice. Mutations in the hr gene in mice provided models for understanding its function and the pathophysiology of related human disorders. The study reviewed the structure, expression patterns, and mutations of the hr gene, exploring its implications in hairlessness, reproductive and immunological defects, and dioxin toxicity susceptibility. The authors speculated on the potential functions of the hr gene product in skin and hair follicle biology.
9 citations,
March 1998 in “Journal of Dermatological Science” Improper regulation of hair follicle processes causes hairlessness.
71 citations,
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67 citations,
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19 citations,
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35 citations,
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February 2024 in “International Journal of Molecular Sciences” Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.
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September 2012 in “Dermatologic Clinics” Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.
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2 citations,
May 2022 in “Stem cell research & therapy” Disrupted stem cell signals in hairpoor mice cause hair loss.
Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.
