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Glossary Hair Follicle Biology

study of hair follicle structure, function, and growth cycles

Hair Follicle Biology is the study of the structure, function, and growth cycles of hair follicles, which are tiny organs in the skin responsible for producing hair. This field examines how hair follicles develop, how they cycle through phases of growth and rest, and how various factors like genetics, hormones, and environmental influences affect hair health and disorders such as alopecia.

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Research

5 / 1000+ results

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.

research Human hair growth in vitro: a model for the study of hair follicle biology

133 citations , July 1994 in “Journal of Dermatological Science”

In this study, the researchers developed an in vitro model that maintains human hair follicles to grow at in vivo rates and observed that factors like EGF and IGF-I influence hair follicle growth and catagen entry.

research Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias

57 citations , August 1999 in “Archives of dermatology”

Hair follicles grow hair and release it through the skin.

research Role of the vitamin D receptor in hair follicle biology

54 citations , January 2007 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that hair follicle homeostasis in mice requires vitamin D receptor expression in keratinocytes, independent of its ligand activation.

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations , October 2009 in “Dermatology”

This study suggests that the action of minoxidil in stimulating hair growth likely occurs at the follicular dermal papilla, though it does not induce new follicle formation.

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Learn

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learn Valproic acid

What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? Valproic acid affects hair follicles by modulating cell signaling and gene regulation.

learn sh-Polypeptide-7

How does sh-Polypeptide-7 help stimulate hair follicle activity or reduce scalp inflammation? sh-Polypeptide-7 is the INCI name for a lab-made form of human growth hormone (somatotropin) — not EGF, which is sh-Oligopeptide-1. Growth hormone and IGF-1 signalling is documented in hair follicle biology, but there is no published human trial of sh-Polypeptide-7 applied to the scalp for hair growth or scalp inflammation.

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

Do exosomes work for people with mild hair loss or only in advanced cases? There is no approved exosome treatment for hair loss and no controlled trial in either mild or advanced cases; the argument that early thinning would respond better is based on follicle biology, not on results.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

learn GHK-Cu

a copper peptide showing promise in both regrowth and reversing gray hair

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn oleic acid

How does Oleic Acid support hair follicle strength and growth? Oleic acid strengthens hair follicles by enhancing hydration and reducing inflammation.

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Community Join

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community I’m in Greece/ abroad and ran out of fin, what will biologically happen from stopping fin for 4-5 weeks?

10 upvotes 4 days ago

Stopping finasteride for 4-5 weeks is unlikely to cause significant hair loss, as hair follicles operate on cycles measured in months. Finasteride can be purchased without a prescription in Greece, making it easy to continue treatment.

community Do hair follicles dies or are dormant ?

in Finasteride/Dutasteride 92 upvotes 1 year ago

Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community Realistic timeline for hair regeneration and follicle cloning?

7 upvotes 6 months ago

Hair regeneration and follicle cloning are considered far from being feasible, with current treatments like finasteride, minoxidil, and hair transplants expected to remain dominant for the next 15-20 years. Some are hopeful that AI advancements might accelerate progress, but many remain skeptical about significant breakthroughs in the near future.

community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

4 upvotes 1 year ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

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Clinics

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Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas