The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

    May 2022 in “ Stem cell research & therapy ”
    Kyu-Yong Choi, Sanghee Park, Seo-Yeon Park, Sungjoo Kim
    Studysummary This study found that hair follicle stem cells in the hairpoor mouse, a model for Marie-Unna hypotrichosis, lose their quiescent state, leading to a disordered hair cycle and contributing to alopecia.
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    Research cited in this study 18

    1. Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence Journal of Investigative Dermatology · 2015
    2. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    3. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    4. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    5. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    6. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012
    7. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    8. A Novel Mutation in Hr Causes Abnormal Hair Follicle Morphogenesis in Hairpoor Mouse, an Animal Model for Marie Unna Hereditary Hypotrichosis Mammalian genome · 2009
    9. Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis Nature Genetics · 2009
    10. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008
    11. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    12. CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice Cancer Research · 2007
    13. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006
    14. A Novel Missense Mutation in the Mouse Hairless Gene Causes Irreversible Hair Loss: Genetic and Molecular Analyses of Hrm1Enu Genomics · 2006
    15. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005
    16. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    17. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    18. The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor Genes & Development · 2001

    Related research 6

    1. Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes Journal of St. Marianna University · 2022
    2. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    3. The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation American Journal Of Pathology · 1999
    4. Basonuclin as a Cell Marker in the Formation and Cycling of the Murine Hair Follicle Differentiation · 1998
    5. Basonuclin as a Cell Marker in the Formation and Cycling of the Murine Hair Follicle Differentiation · 1998
    6. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996