Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence

    June 2015 in “ Journal of Investigative Dermatology ”
    Shin‐Ichi Osada, Naoko Minematsu, Fumino Oda … Shigeo Ohno
    Studysummary This study observed that epidermal-specific deletion of aPKCλ in mice disrupts hair follicle stem cell quiescence, leading to altered hair follicle cycling and skin anomalies.
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    Research cited in this study 9

    1. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    2. A Family Business: Stem Cell Progeny Join the Niche to Regulate Homeostasis Nature Reviews Molecular Cell Biology · 2012
    3. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    4. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    5. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    6. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    7. The Hair Cycle Journal of Cell Science · 2006
    8. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and in Transgenic Mice Molecular and Cellular Biology · 1993
    9. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and In Transgenic Mice Molecular and Cellular Biology · 1993

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