Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence

June 2015 in “ Journal of Investigative Dermatology ”

Shin‐Ichi Osada, Naoko Minematsu, Fumino Oda, Kazunori Akimoto, Seiji Kawana, Shigeo Ohno

atypical protein kinase C lambda aPKCλ hair follicle stem cell HFSC hair cycling quiescence-inducing factors Fgf18 Bmp6 Lrig1 hyperplasia anagen phase bulge stem cells

TLDR aPKCλ is crucial for keeping hair follicle stem cells inactive and maintaining normal hair growth.

The study demonstrated that the atypical protein kinase C isoform, aPKCλ, was essential for maintaining hair follicle stem cell (HFSC) quiescence and proper hair cycling. In mice with epidermal-specific deletion of aPKCλ, there was abnormal hair follicle cycling, progressive hair loss, and altered epidermal differentiation. This was due to decreased expression of quiescence-inducing factors Fgf18 and Bmp6, leading to dysregulated HFSC marker expression and increased Lrig1-positive cells, causing hyperplasia and prolonged anagen-like phases. The persistent activation of bulge stem cells gradually depleted HFSC reservoirs, highlighting the critical role of aPKCλ in regulating signaling pathways for HFSC quiescence.

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