Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

    May 2009 in “ Cell stem cell ”
    Kim B. Jensen, Charlotte Collins, Elisabete Nascimento … Fiona M. Watt
    Studysummary This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.
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    Research cited in this study 15

    1. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    2. Dynamic Regulation of Retinoic Acid-Binding Proteins in Developing, Adult, and Neoplastic Skin Reveals Roles for β-Catenin and Notch Signaling Developmental biology · 2008
    3. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    4. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007
    5. New Hair From Healing Wounds Nature · 2007
    6. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    7. Keratin Expression Provides Novel Insight Into the Morphogenesis and Function of the Companion Layer in Hair Follicles Journal of Investigative Dermatology · 2006
    8. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    9. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    10. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    11. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    12. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    13. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    14. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    15. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001

    Related research 2

    1. Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine Tissue Engineering Part B-reviews · 2012
    2. Epidermal Stem Cell Fate: What Can We Learn from Embryonic Stem Cells? Cell & tissue research/Cell and tissue research · 2007