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GlossaryLeucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1)

protein regulating cell growth and maintaining stem cells

Leucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1) is a protein that plays a crucial role in regulating cell growth and maintaining stem cell populations in various tissues, including the skin and hair follicles. It acts as a tumor suppressor and helps control the signaling pathways that can lead to cell proliferation, making it important for both normal tissue maintenance and cancer prevention.

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research Lrig1 Expression in Human Sebaceous Gland Tumors

3 citations, May 2016 in “Dermatopathology”

Lrig1 could be a marker for advanced sebaceous carcinoma.

research Identification of Two Distinct Stem Cell Clusters, Lrig1-Derived and Wnt/CD44-Dependent, in Corneal Epithelium

April 2018 in “Journal of Investigative Dermatology”

The conclusion is that the cornea has two types of stem cells, with Lrig1+ cells being key for renewal in aging corneas, independent of CD44.

research Lrig1-Expressing Epidermal Progenitors Require SCD1 to Maintain the Dermal Papilla Niche

March 2023 in “Scientific reports”

Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.

research Specific In Vivo Ablation of Lrig1-Positive Follicular Stem Cells Results in Sebaceous Gland Loss in Mice

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing Lrig1-positive stem cells in mice causes temporary loss of sebaceous glands.

research HPV8 E6 Leads to Lrig1+ Keratinocyte Stem Cell Expansion

July 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

HPV8 E6 gene causes growth of certain skin stem cells.

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