Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?

October 2007 in “ Cell Stem Cell ”

Philip H. Jones, Benjamin D. Simons, Fiona M. Watt

epidermal stem cells transit amplifying cells hair follicle interfollicular epidermis sebaceous glands epidermal proliferative unit label-retaining cells AhcreER transgenic mouse lineage tracing clonal evolution proliferating basal cells stem cells TA cells skin epidermis EPU LRC AhcreER mouse basal cells

Studysummary New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

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This study identified a novel MTS24-positive murine keratinocyte population with increased colony-forming ability, suggesting these cells may serve as a new reservoir of proliferative progenitor or stem cells in hair follicles.

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This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.