Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin

October 1994 in “ The Journal of Cell Biology ”

Ken Takahashi, Janet Folmer, Pierre A. Coulombe

keratin 16 keratin 6 keratin 17 keratinization hair follicle outer root sheath epidermis keratinocytes desmosomes cytoarchitecture

Studysummary This study demonstrates that overexpression of K16 in transgenic mice disrupts normal keratinization, leading to hyperkeratosis, acanthosis, and alterations in the skin's epithelial cells.

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Research cited in this study

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research Cyclic Hair Loss and Regrowth in Transgenic Mice Overexpressing an Intermediate Filament Gene

93 citations , May 1990 in “The EMBO Journal”

Mice with extra sheep genes had hair that fell out and regrew in cycles.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.

research A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin

156 citations , January 1989 in “Genes & Development”

This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.

research A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression

141 citations , February 1988 in “Molecular and Cellular Biology”

This study found that despite strong homology between two K16 genes, only one encoded a functional protein that assembled into keratin filaments in epithelial cells, possibly due to promoter strength differences.

research A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression

38 citations , February 1988 in “Molecular and Cellular Biology”

This study found that among the two highly homologous K16 genes on chromosome 17, only one produced a functional protein due to stronger promoter activity.

research Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

135 citations , November 1987 in “Differentiation”

This study found that cultured outer root sheath cells from human hair follicles expressed a keratin profile similar to their in vivo environment, indicating environmental influence on keratin expression.

research Three cDNA Sequences of Mouse Type I Keratins: Cellular Localization of the mRNAs in Normal and Hyperproliferative Tissues

57 citations , January 1987 in “Journal of Biological Chemistry”

This study identified and sequenced several keratin cDNA clones showing distinct expression patterns in mouse epithelia, with in situ hybridization highlighting differences in keratin distribution between normal and hyperproliferative tissues.

research Expression of Epidermal Keratins and Filaggrin During Human Fetal Skin Development

292 citations , October 1985 in “The Journal of Cell Biology”

This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.