Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin

    October 1994 in “ The Journal of Cell Biology ”
    Ken Takahashi, Janet Folmer, Pierre A. Coulombe
    Studysummary This study demonstrates that overexpression of K16 in transgenic mice disrupts normal keratinization, leading to hyperkeratosis, acanthosis, and alterations in the skin's epithelial cells.
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    Research cited in this study 8

    1. Cyclic Hair Loss and Regrowth in Transgenic Mice Overexpressing an Intermediate Filament Gene The EMBO Journal · 1990
    2. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989
    3. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989
    4. A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression Molecular and Cellular Biology · 1988
    5. A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression Molecular and Cellular Biology · 1988
    6. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987
    7. Three cDNA Sequences of Mouse Type I Keratins: Cellular Localization of the mRNAs in Normal and Hyperproliferative Tissues Journal of Biological Chemistry · 1987
    8. Expression of Epidermal Keratins and Filaggrin During Human Fetal Skin Development The Journal of Cell Biology · 1985

    Related research 3

    1. Delayed Wound Healing in Keratin 6a Knockout Mice Molecular and Cellular Biology · 2000
    2. Keratin Expression in Basal Cell Carcinomas British Journal of Dermatology · 1992
    3. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989