Epidermal Stem Cell Diversity and Quiescence

August 2009 in “ EMBO molecular medicine ”

Fiona M. Watt, Kim B. Jensen

epidermal stem cells Wnt signaling EGF receptor signaling NFATc1 Lrig1 hair follicles junctional zone multi-lineage differentiation self-renewal differentiation

TLDR Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

The 2009 paper "Epidermal stem cell diversity and quiescence" by Fiona M. Watt and Kim B. Jensen revealed significant diversity among epidermal stem cells, which are located in different regions and vary in activity levels. These cells maintain the epidermis through self-renewal and differentiation, with the ability to exhibit multi-lineage differentiation in response to injury or genetic changes. Key findings included the roles of Wnt and EGF receptor signaling in differentiation, and the identification of NFATc1 and Lrig1 in maintaining stem cell quiescence in hair follicles and the junctional zone, respectively. The study highlighted the complex interplay between various signaling pathways and set the stage for further exploration of the relationships between different stem cell populations and their roles in epidermal homeostasis and repair.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

82 citations, May 2009 in “Development”

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations, February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Dynamic Regulation of Retinoic Acid-Binding Proteins in Developing, Adult, and Neoplastic Skin Reveals Roles for β-Catenin and Notch Signaling

84 citations, December 2008 in “Developmental biology”

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations, October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations, November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

research Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?

153 citations, October 2007 in “Cell Stem Cell”

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research The Hair Cycle

375 citations, February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations, December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells

384 citations, June 2005 in “Genes & development”

β-catenin is essential for stem cell activation and proliferation in hair follicles.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations, June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations, August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

Similar Research

5 / 1000+ results

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations, August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

research The Epithelial Stem Cell Niche in Skin

9 citations, January 2017 in “Elsevier eBooks”

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

research Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development

25 citations, September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research Transcriptional Control of Epidermal Stem Cells

4 citations, January 2013 in “Advances in Experimental Medicine and Biology”

Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.