Proinflammatory Cytokines Regulate Epidermal Stem Cells in Wound Epithelialization
June 2020
in “
Stem Cell Research & Therapy
”
proinflammatory cytokines epidermal stem cells wound epithelialization IL-1 IL-6 IL-17 TNF-α keratinocyte migration keratinocyte proliferation keratinocyte differentiation anti-TNF-α antibodies chronic wounds acute wound healing scar formation tumorigenesis interleukin-1 interleukin-6 interleukin-17 tumor necrosis factor-alpha anti-TNF-α
TLDR Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.
Xiao et al. reviewed the complex role of proinflammatory cytokines in the regulation of epidermal stem cells during wound epithelialization. They found that cytokines such as IL-1, IL-6, IL-17, and TNF-α are crucial for the healing process, promoting keratinocyte migration, proliferation, and differentiation. While these cytokines are beneficial for acute wound healing, their overproduction can lead to chronic wounds. Therapeutic strategies targeting these cytokines have shown promise, with treatments like anti-TNF-α antibodies improving wound healing by reducing inflammation. However, challenges remain, including scar formation and tumorigenesis. The review suggests that further research into stem cell and immune cell interactions is essential for developing more effective and cost-efficient therapies for skin wounds.
