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GlossaryTumorigenesis

process of normal cells transforming into cancerous tumors

Tumorigenesis, also known as tumor formation, is the process by which normal cells transform into cancer cells and begin to grow uncontrollably, forming a mass or tumor. This process involves a series of genetic mutations and changes in cellular behavior that allow the cells to evade normal growth controls, resist cell death, and often gain the ability to invade surrounding tissues and spread to other parts of the body.

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research Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis

29 citations, July 2014 in “PloS one”

Meis1 is crucial for skin health and tumor development.

research Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis

7 citations, February 2022 in “Stem cell reviews and reports”

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.

research The Role of Wnt and Shh Signaling Systems in Noggin-Induced Tumorigenesis

March 2024 in “Vestnik Rossijskogo universiteta družby narodov. Seriâ Agronomiâ i životnovodstvo”

Wnt and Shh signaling are key in noggin-induced tumors, and blocking them can slow tumor growth.

research Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects Against Malignant Progression

15 citations, July 2013 in “Cell Reports”

Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.

research Integrin α3β1 in Hair Bulge Stem Cells Modulates CCN2 Expression and Promotes Skin Tumorigenesis

5 citations, May 2020 in “Life science alliance”

Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.