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GlossaryTumorigenesis

process of normal cells transforming into cancerous tumors

Tumorigenesis, also known as tumor formation, is the process by which normal cells transform into cancer cells and begin to grow uncontrollably, forming a mass or tumor. This process involves a series of genetic mutations and changes in cellular behavior that allow the cells to evade normal growth controls, resist cell death, and often gain the ability to invade surrounding tissues and spread to other parts of the body.

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research Plasticity of Differentiated Cells in Wound Repair and Tumorigenesis, Part II: Skin and Intestine

40 citations, August 2018 in “Disease Models & Mechanisms”

Mature cells can re-enter the cell cycle and potentially lead to cancer.

research Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis

29 citations, July 2014 in “PloS one”

Meis1 is crucial for skin health and tumor development.

research Keratin-6 Driven ODC Expression in Hair Follicle Keratinocytes Enhances Stemness and Tumorigenesis by Negatively Regulating Notch

8 citations, August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

research Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis

8 citations, November 2013 in “PLOS ONE”

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

research Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis

7 citations, February 2022 in “Stem cell reviews and reports”

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community (Serious) News and discussion on potential treatments

in Treatment 27 upvotes 2 months ago

Current hair loss treatments include finasteride, dutasteride, minoxidil, and derma rolling. New treatments like TDM-105795, GT20029, and others show promise but require more testing and time before approval.

community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.