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    Glossary Tumorigenesis

    process of normal cells transforming into cancerous tumors

    Tumorigenesis, also known as tumor formation, is the process by which normal cells transform into cancer cells and begin to grow uncontrollably, forming a mass or tumor. This process involves a series of genetic mutations and changes in cellular behavior that allow the cells to evade normal growth controls, resist cell death, and often gain the ability to invade surrounding tissues and spread to other parts of the body.

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    1. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis The EMBO Journal · 2013 · 65 citations
    2. Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine Disease Models & Mechanisms · 2018 · 40 citations
    3. Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis PloS one · 2014 · 29 citations
    4. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch Biochemical and Biophysical Research Communications · 2014 · 8 citations
    5. Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis PLOS ONE · 2013 · 8 citations
    6. Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis Stem cell reviews and reports · 2022 · 7 citations
    7. Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis 2021 · 1 citations
    8. The role of Wnt and Shh signaling systems in noggin-induced tumorigenesis Vestnik Rossijskogo universiteta družby narodov. Seriâ Agronomiâ i životnovodstvo · 2024
    9. Role of alkaline ceramidase 1 (Acer1) in regulating epidermal homeostasis and tumorigenesis Academic Commons (Stony Brook University) · 2017
    10. Abstract C4: Sp2: A regulator of stem cell differentiation and tumorigenesis Cancer Research · 2009
    11. Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression Cell Reports · 2013 · 15 citations
    12. Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis Life science alliance · 2020 · 5 citations
    13. The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed Amino Acids · 2026
    14. ROLE OF STAT3 IN KERATINOCYTE STEM CELLS DURING SKIN TUMORIGENESIS DigtalCommons @ Texas Medical Center Library (Texas Medical Center) · 2012
    15. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis 2008 · 148 citations
    16. Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069. PubMed · 2002 · 143 citations
    17. Long-term toxicologic and tumorigenesis studies on an oral contraceptive agent in albino rats Toxicology and Applied Pharmacology · 1970 · 61 citations
    18. Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1 Molecular and Cellular Biology · 2004 · 48 citations
    19. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways American Journal Of Pathology · 2009 · 45 citations
    20. Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride The Journal of Steroid Biochemistry and Molecular Biology · 2015 · 21 citations
    21. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Amino Acids · 2013 · 17 citations
    22. Fibrotic enzymes modulate wound‐induced skin tumorigenesis EMBO Reports · 2021 · 15 citations
    23. The role of <i>Atg5</i> gene in tumorigenesis under autophagy deficiency conditions The Kaohsiung Journal of Medical Sciences · 2024 · 4 citations
    24. Involvement of hair follicles in skin tumorigenesis, skin homeostasis and wound healing Medical Research Archives · 2025
    25. Loss of TET2 Tips the Scales Toward Tumorigenesis 2022
    26. 646 SOX4 is essential for melanoma tumorigenesis Journal of Investigative Dermatology · 2016
    27. Hedgehog-Wnt Interactions during Pathologic Epithelial Bud Development and Skin Tumorigenesis. Deep Blue (University of Michigan) · 2008
    28. Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis Carcinogenesis · 2006 · 37 citations
    29. Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth Journal of Dermatological Science · 2008 · 7 citations
    30. ROLE OF THE TRANSCRIPTION FACTOR SOX9 IN THE TUMORIGENESIS OF SOME DOMESTIC ANIMALS NEOPLASMS Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · 2016