TLDR Porcine acellular dermal matrix treatment helps wounds heal faster and reduces scarring by affecting Jag1 in skin stem cells.
The document from January 2, 2018, summarizes a study that explored the impact of Jag1 expression in epidermal stem cells (ESCs) on wound healing and scar formation, and how porcine acellular dermal matrix (ADM) treatment influences this process. The study found that Jag1 plays a critical role in regulating the differentiation of ESCs into myofibroblasts (MFB), which are associated with scar formation. In vivo experiments showed that knocking out Jag1 in ESCs led to delayed wound healing and increased scar formation, while porcine ADM treatment promoted faster wound closure and reduced scarring. This treatment worked by enhancing the Notch/Jagged1 signaling pathway in ESCs, as indicated by increased expression of Jag1, Notch1, and Hes1 in wound tissues. The study involved 10 mice per experimental group and demonstrated statistical significance with P<0.05. These findings suggest that targeting Jag1 expression in ESCs and using porcine ADM treatment could be effective strategies for improving wound healing and minimizing scar formation.
113 citations,
June 2015 in “Stem Cell Research & Therapy” Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
26 citations,
July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
835 citations,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
June 2024 in “Research Square (Research Square)” Jagged-1 in skin Tregs is crucial for timely wound healing by recruiting specific immune cells.
65 citations,
June 2020 in “Stem Cell Research & Therapy” Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.
39 citations,
July 2021 in “Stem Cell Research & Therapy” Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.
11 citations,
March 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific group of skin stem cells was found to help maintain hair follicle cells.
188 citations,
March 2018 in “Frontiers in Immunology” Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.
