Biochemistry of Epidermal Stem Cells

July 2012 in “ Biochimica et Biophysica Acta (BBA) - General Subjects ”

Richard L. Eckert, Gautam Adhikary, S. Balasubramanian, Ellen A. Rorke, Mohan C. Vemuri, Shayne Boucher, Jackie R. Bickenbach, Candace L. Kerr

epidermal stem cells skin maintenance skin repair stem cell markers niche locations skin function skin cancer signaling pathways microRNAs CD200 keratin 15 Lgr6+ cells sebaceous gland mutations miR-203 keratinocyte differentiation mouse models skin stem cells

TLDR The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

The 2013 review examined the biochemistry of epidermal stem cells, which are vital for skin maintenance and repair. It covered the identification of stem cell markers, the understanding of their niche locations, and their role in normal skin function and cancer. The review concluded that the epidermis contains multiple stem cell populations, each responsible for different structures, and that these cells are key to repairing damaged skin. It also discussed the potential of these cells in treating skin diseases and cancer, and the importance of signaling pathways and microRNAs in stem cell regulation. Specific markers for human and mouse hair follicle stem cells were identified, such as CD200 and keratin 15, and the role of Lgr6+ cells in the sebaceous gland was noted. The paper suggested that mutations in stem cells could lead to skin cancer and highlighted the role of miRNAs like miR-203 in keratinocyte differentiation and skin stem cell regulation. The research emphasized the progress made in understanding stem cell behavior through mouse models and its implications for treating stem cell-related conditions.

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Research cited in this study

19 / 19 results

research Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle

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New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

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MTS24 marks a new type of skin cell that helps hair growth and repair.

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Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

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β-catenin is essential for stem cell activation and proliferation in hair follicles.

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Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

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Stem cells are in deep skin layers, while differentiating cells are in shallow layers.

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Involucrin gene expression is controlled by specific proteins and signaling pathways.

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The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

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Keratin 19 helps identify skin stem cells, with its presence varying by body location, age, and culture stage.

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