Dissecting the Bulge in Hair Regeneration

    February 2012 in “ Journal of Clinical Investigation ”
    Peggy Myung, Mayumi Ito
    Studysummary This review discusses recent advances in understanding hair follicle stem cell dynamics and interactions, but it reports no new experimental findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 23

    1. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    2. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    3. Basal Cell Carcinomas in Mice Arise from Hair Follicle Stem Cells and Multiple Epithelial Progenitor Populations Journal of Clinical Investigation · 2011
    4. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    5. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    6. Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma Nature Cell Biology · 2010
    7. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    8. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    9. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    10. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    11. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    12. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    13. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    14. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    15. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    16. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    17. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    18. Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration Journal of Investigative Dermatology · 2001
    19. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    20. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    21. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    22. The Formation of Vellus Hair Follicles from Human Adult Epidermis Journal of Investigative Dermatology · 1956
    23. Critical Stages of Hair Development and Pigmentation in the Mouse Physiological zoology · 1951

    Related research 7

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    2. Increased PHGDH Expression Uncouples Hair Follicle Cycle Progression and Promotes Inappropriate Melanin Accumulation bioRxiv (Cold Spring Harbor Laboratory) · 2018
    3. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    4. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    5. Functionally Distinct Melanocyte Populations Revealed by Reconstitution of Hair Follicles in Mice Pigment Cell & Melanoma Research · 2010
    6. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    7. Melanocyte Subpopulation Turnover During the Human Hair Cycle: An Immunohistochemical Study Pigment cell research · 2000