Increased PHGDH Expression Uncouples Hair Follicle Cycle Progression and Promotes Inappropriate Melanin Accumulation

    January 2018 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Katherine Mattaini, Mark R. Sullivan, Allison N. Lau … Matthew G. Vander Heiden

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study developed a mouse model to mimic PHGDH gene copy number gain, finding that increased PHGDH expression leads to abnormal melanin production, which may offer insights into its role in melanoma.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 10

    1. Characterization of a New, Inducible Transgenic Mouse Model with GFP Expression in Melanocytes and Their Precursors Gene Expression Patterns · 2017
    2. mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration Journal of molecular cell biology/Journal of Molecular Cell Biology · 2015
    3. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    4. The Human Hair Follicle, A Bistable Organ? Experimental Dermatology · 2012
    5. Scratching the Surface of Skin Development Nature · 2007
    6. The Follicular Automaton Model: Effect of Stochasticity and Synchronization of Hair Cycles Journal of theoretical biology · 2002
    7. Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    8. Melanogenesis Is Coupled to Murine Anagen: New Concepts for the Role of Melanocytes and Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    9. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    10. Growth of the Hair Physiological Reviews · 1954

    Related research 2

    1. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    2. Functionally Distinct Melanocyte Populations Revealed by Reconstitution of Hair Follicles in Mice Pigment Cell & Melanoma Research · 2010